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A mini review: Shape memory polymers for biomedical applications

Kaojin Wang, Satu Strandman, X. X. Zhu

《化学科学与工程前沿（英文）》 2017年第11卷第2期页码 143-153 doi: 10.1007/s11705-017-1632-4

摘要： Shape memory polymers (SMPs) are smart materials that can change their shape in a pre-defined manner under a stimulus. The shape memory functionality has gained considerable interest for biomedical applications, which require materials that are biocompatible and sometimes biodegradable. There is a need for SMPs that are prepared from renewable sources to be used as substitutes for conventional SMPs. In this paper, advances in SMPs based on synthetic monomers and bio-compounds are discussed. Materials designed for biomedical applications are highlighted.

关键词： shape memory polymer biodegradability biocompatibility biomedical application bile acids

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Systems biomedical analysis of Schistosoma japonicum

Ze-Guang HAN MD,

《医学前沿（英文）》 2010年第4卷第2期页码 157-165 doi: 10.1007/s11684-010-0034-5

摘要： Human schistosomiasis, caused mainly by three principal species including , , and , remains a major public health concern worldwide. is prevalent in southern China, being a major disease risk for 66 million people. The blood fluke has a complex life cycle for survival: as a free-living form in fresh water and as a parasite in the snail intermediate and vertebrate definitive hosts. Systems-based biomedical analyses, including genomic, transcriptomic, proteomic and metabonomic approaches, have been performed on the schistosome. These comprehensive investigations have not only characterized the genomic features but also chartered gene and protein expression profiles across genders and developmental stages. The integration of the huge information will lay a global and solid foundation for the molecular architecture of the biology, pathogenesis, and host-parasite interactions of the human blood fluke, which will facilitate the development of a new antischistosomal vaccine and drugs as well as diagnostic markers for the treatment and control of schistosomiasis.

关键词： Schistosoma japonicum systems biomedical analysis

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Fluorescent probes and functional materials for biomedical applications

《化学科学与工程前沿（英文）》 2022年第16卷第10期页码 1425-1437 doi: 10.1007/s11705-022-2163-1

摘要： Due to their simplicity in preparation, sensitivity and selectivity, fluorescent probes have become the analytical tool of choice in a wide range of research and industrial fields, facilitating the rapid detection of chemical substances of interest as well as the study of important physiological and pathological processes at the cellular level. In addition, many long-wavelength fluorescent probes developed have also proven applicable for in vivo biomedical applications including fluorescence-guided disease diagnosis and theranostics (e.g., fluorogenic prodrugs). Impressive progresses have been made in the development of sensing agents and materials for the detection of ions, organic small molecules, and biomacromolecules including enzymes, DNAs/RNAs, lipids, and carbohydrates that play crucial roles in biological and disease-relevant events. Here, we highlight examples of fluorescent probes and functional materials for biological applications selected from the special issues “Fluorescent Probes” and “Molecular Sensors and Logic Gates” recently published in this journal, offering insights into the future development of powerful fluorescence-based chemical tools for basic biological studies and clinical translation.

关键词： fluorescent probes imaging cell biomedicine biomolecules

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Biomedical sensor technologies on the platform of mobile phones

Lin LIU, Jing LIU

《机械工程前沿（英文）》 2011年第6卷第2期页码 160-175 doi: 10.1007/s11465-011-0216-0

摘要：

Biomedical sensors have been widely used in various areas of biomedical practices, which play an important role in disease detection, diagnosis, monitoring, treatment, health management, and so on. However, most of them and their related platforms are generally not easily accessible or just too expensive or complicated to be kept at home. As an alternative, new technologies enabled from the mobile phones are gradually changing such situations. As can be freely available to almost everyone, mobile phone offers a unique way to improve the conventional medical care through combining with various biomedical sensors. Moreover, the established systems will be both convenient and low cost. In this paper, we present an overview on the state-of-art biomedical sensors, giving a brief introduction of the fundamental principles and showing several new examples or concepts in the area. The focus was particularly put on interpreting the technical strategies to innovate the biomedical sensor technologies based on the platform of mobile phones. Some challenging issues, including feasibility, usability, security, and effectiveness, were discussed. With the help of electrical and mechanical technologies, it is expected that a full combination between the biomedical sensors and mobile phones will bring a bright future for the coming pervasive medical care.

关键词： biomedical sensor pervasive technology mobile phone combined system health management

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Introduction to the Special Section on Biomedical Devices for Personal Health Applications

I-Ming CHEN

《机械工程前沿（英文）》 2011年第6卷第1期页码 1-2 doi: 10.1007/s11465-011-0210-6

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Functional ferritin nanoparticles for biomedical applications

Zhantong Wang, Haiyan Gao, Yang Zhang, Gang Liu, Gang Niu, Xiaoyuan Chen

《化学科学与工程前沿（英文）》 2017年第11卷第4期页码 633-646 doi: 10.1007/s11705-017-1620-8

摘要： Ferritin, a major iron storage protein with a hollow interior cavity, has been reported recently to play many important roles in biomedical and bioengineering applications. Owing to the unique architecture and surface properties, ferritin nanoparticles offer favorable characteristics and can be either genetically or chemically modified to impart functionalities to their surfaces, and therapeutics or probes can be encapsulated in their interiors by controlled and reversible assembly/disassembly. There has been an outburst of interest regarding the employment of functional ferritin nanoparticles in nanomedicine. This review will highlight the recent advances in ferritin nanoparticles for drug delivery, bioassay, and molecular imaging with a particular focus on their biomedical applications.

关键词： nanomedicine ferritin drug delivery bioassay molecular imaging

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Personalized biomedical devices & systems for healthcare applications

I-Ming CHEN, Soo Jay PHEE, Zhiqiang LUO, Chee Kian LIM

《机械工程前沿（英文）》 2011年第6卷第1期页码 3-12 doi: 10.1007/s11465-011-0209-z

摘要：

With the advancement in micro- and nanotechnology, electromechanical components and systems are getting smaller and smaller and gradually can be applied to the human as portable, mobile and even wearable devices. Healthcare industry have started to benefit from this technology trend by providing more and more miniature biomedical devices for personalized medical treatments in order to obtain better and more accurate outcome. This article introduces some recent development in non-intrusive and intrusive biomedical devices resulted from the advancement of niche miniature sensors and actuators, namely, wearable biomedical sensors, wearable haptic devices, and ingestible medical capsules. The development of these devices requires carful integration of knowledge and people from many different disciplines like medicine, electronics, mechanics, and design. Furthermore, designing affordable devices and systems to benefit all mankind is a great challenge ahead. The multi-disciplinary nature of the R&D effort in this area provides a new perspective for the future mechanical engineers.

关键词： personalized medical devices wearable sensor haptic device ingestible medical capsule

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评论——Erasmus大学Thoraxcenter生物医疗工程系的最新成果

Bertrand van Ee

《工程（英文）》 2015年第1卷第1期页码 20-20 doi: 10.15302/J-ENG-2015020

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声场驱动的微操作技术及其生物医学应用

Zhichao Ma, Peer Fischer

《工程（英文）》 2023年第24卷第5期页码 13-16 doi: 10.1016/j.eng.2022.06.006

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磁控螺旋形微纳米机器人在生物医学方面的应用 Review

邱发敏, Bradley J. Nelson

《工程（英文）》 2015年第1卷第1期页码 21-26 doi: 10.15302/J-ENG-2015005

摘要：

磁控螺旋形微纳米机器人可在低强度旋转磁场（<10 mT）的驱动下，实现亚微米精度的三维（3D）游动。由于低强度磁场对细胞和组织无害，磁控螺旋形微纳米机器人在生物医学方面有很大的应用前景，如微创手术、细胞操作和分析以及靶向治疗。本文系统介绍了磁控螺旋形微纳米机器人的制造方法、运动控制和生物医学应用。

关键词：磁控螺旋形微纳米机器人可游动微纳米机器人人造细菌鞭毛（ABFs）功能化生物医学应用

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A bionic approach for the mechanical and electrical decoupling of an MEMS capacitive sensor in ultralow force measurement

《机械工程前沿（英文）》 2023年第18卷第2期 doi: 10.1007/s11465-023-0747-1

摘要： Capacitive sensors are efficient tools for biophysical force measurement, which is essential for the exploration of cellular behavior. However, attention has been rarely given on the influences of external mechanical and internal electrical interferences on capacitive sensors. In this work, a bionic swallow structure design norm was developed for mechanical decoupling, and the influences of structural parameters on mechanical behavior were fully analyzed and optimized. A bionic feather comb distribution strategy and a portable readout circuit were proposed for eliminating electrostatic interferences. Electrostatic instability was evaluated, and electrostatic decoupling performance was verified on the basis of a novel measurement method utilizing four complementary comb arrays and application-specific integrated circuit readouts. An electrostatic pulling experiment showed that the bionic swallow structure hardly moved by 0.770 nm, and the measurement error was less than 0.009% for the area-variant sensor and 1.118% for the gap-variant sensor, which can be easily compensated in readouts. The proposed sensor also exhibited high resistance against electrostatic rotation, and the resulting measurement error dropped below 0.751%. The rotation interferences were less than 0.330 nm and (1.829 × 10⁻⁷)°, which were 35 times smaller than those of the traditional differential one. Based on the proposed bionic decoupling method, the fabricated sensor exhibited overwhelming capacitive sensitivity values of 7.078 and 1.473 pF/µm for gap-variant and area-variant devices, respectively, which were the highest among the current devices. High immunity to mechanical disturbances was maintained simultaneously, i.e., less than 0.369% and 0.058% of the sensor outputs for the gap-variant and area-variant devices, respectively, indicating its great performance improvements over existing devices and feasibility in ultralow biomedical force measurement.

关键词： micro-electro-mechanical system capacitive sensor bionics operation instability mechanical and electrical decoupling biomedical force measurement

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生物医学工程——材料、器械和技术创新铸就美好未来

屠海令, 张兴栋

《工程（英文）》 2021年第7卷第12期页码 1653-1654 doi: 10.1016/j.eng.2021.10.005

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生物医用有色金属材料研究现状与未来发展

关绍康,朱世杰,郑玉峰,王云兵,张兴栋

《中国工程科学》 2023年第25卷第1期页码 104-112 doi: 10.15302/J-SSCAE-2023.01.008

摘要：

生物医用有色金属材料发展迅速，形成了适应不同体内环境、不同组织的医用有色金属材料及器件体系；着眼未来开展领域研究规划，提升新型医用有色金属材料及器件的临床应用水平，兼具理论研究与实践应用价值。本文论述了生物医用有色金属材料在耐蚀性、耐磨性、疲劳强度及韧性、生物适配性等方面的关键性能要求，系统梳理了永久性植入有色金属材料、生物可降解有色金属材料、多孔医用有色金属材料、医用有色金属表面改性等细分领域的研究进展、发展趋势与科学问题。在凝练各类生物医用有色金属材料未来研究方向的基础上，提出了加强基础与关键核心技术研究、组建“产学研医监”协同创新体、建立相关标准及规范、培育高精尖人才体系等发展建议，以期为新型材料发展布局与前沿技术研发提供先导性参考。

关键词：生物医用有色金属材料；永久性植入有色金属材料；生物可降解有色金属材料；多孔医用有色金属材料；医用有色金属表面改性

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面向医学应用的3D 打印技术现状综述 Review

严倩,董汉华,苏瑾,韩建华,宋波,魏青松, 史玉升

《工程（英文）》 2018年第4卷第5期页码 729-742 doi: 10.1016/j.eng.2018.07.021

摘要：

器官移植供体短缺一直是世界各国医学界面临的重大难题之一。传统方法不可避免地存在并发症、二次损伤和供体来源有限等潜在问题。3D 打印技术具有解决目前这些问题的潜力，可用于快速制造个性化组织工程支架、细胞原位修复组织缺陷，甚至直接打印组织和器官。打印的植入体和器官不仅与患者的受损组织完美匹配，而且能够调控材料微结构和细胞排列，促进细胞生长和分化。因此，这类植入体有望实现组织修复，甚至最终解决供体短缺问题。本文总结了3D 打印在医学领域相关研究和最新进展的四个层次，介绍了不同类型的生物医用材料，并讨论了医学应用中3D 打印所需材料和构建体外细胞质基质（ECM）存在的问题和未来的发展方向。

关键词： 3D 打印植入体支架生物医学材料

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信息科学应引领未来的生物医学研究 Perspective

Kenta Nakai

《工程（英文）》 2019年第5卷第6期页码 1155-1158 doi: 10.1016/j.eng.2019.07.023

摘要：

笔者从长期回顾的角度阐述了对人工智能（AI）/数据科学与生物医学之间关系的看法。随着新技术的不断出现，现代生物医学的发展持续加速。由于所有生命系统基本上都受其自身DNA中信息的支配，因此信息科学对生物医学的研究具有特别重要的意义。与物理学不同，在生物学中没有发现（或很少有）主导定律。因此，在生物学中，“数据到知识”方法很重要。人工智能在历史上一直应用于生物医学，最近的新闻表明，基于人工智能的方法在国际蛋白质结构预测竞争中获得了最佳性能，这可能被视为该领域的另一个里程碑。类似的方法可能有助于解决基因组序列解释中的问题，如确定患者基因组中的癌症驱动突变。最近，新一代测序（NGS）的爆炸性发展已产生大量数据，并且这种趋势将加速。NGS不仅用于“读取”DNA序列，而且还用于在单细胞水平上获得各种类型的信息。这些数据可以视为气候模拟中的网格数据点。数据科学和人工智能对于这些数据的综合解释/模拟都将变得至关重要，并将在未来的精密医学中起主导作用。

关键词：数据科学人工智能下一代测序脱氧核糖核酸癌症基因组单细胞转录组学